High-throughput screening of drug leads
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules. Santanilla et al.
annotated by Gurshagan Kandhola
In early stages of drug discovery, large quantities of materials are rarely available. The authors in this paper have come up with a miniaturized automation platform enabling...
annotations posted 08/23/2016
CSI Africa: Tracking ivory poachers
Genetic assignment of large seizures of elephant ivory reveals Africa’s major poaching hotspots. Wasser et al.
annotated by Travis Dittmer and Paul Beardsley
The illegal ivory trade threatens the persistence of stable wild African elephant populations. The underground and covert nature of poaching makes it difficult to...
annotations posted 08/18/2016
A caffeine jolt gives bees a buzz to remember
Caffeine in Floral Nectar Enhances a Pollinator's Memory of Reward. Wright et al.
annotated by Tara Bracken
Many compounds produced by plants as a defense against predation are known to have interesting effects on humans. One such drug, caffeine, improves human memory and alertness, lending increased focus and a manic...
annotations posted 08/08/2016
Limb regeneration: fact or (science) fiction?
Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate. Kumar et al.
annotated by Jason Librande
Human limb regeneration has been a common theme throughout fiction. The Amazing Spider-Man makes good use of this idea by telling the story of a scientist who, while trying to...
annotations posted 07/29/2016
Expanding the limits of optical resolution
Expansion microscopy. Chen et al.
annotated by Bob Kao
How do scientists examine organ development and diseases at subcellular resolution? Recent cutting-edge imaging modalities—called superresolution microsopy—enable scientists to examine molecules at nanoscale resolution. The authors of this article discovered a new...
annotations posted 07/27/2016
Can we handle the power of CRISPR?
The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations. Gantz et al.
annotated by Jennifer Susan Stancill
The CRISPR-Cas9 gene editing system has taken the molecular biology world by storm. Originally discovered in Streptococcus pyogenes as a way for the bacteria to fight off...
annotations posted 07/26/2016
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Katsimpardi et al.
annotated by Eshini Panditharatna
What happens when an old mouse and young mouse are sewn together to create one vascular system? Scientists were able to identify the influence caused by factors unique to the...
annotations posted 07/22/2016
One vaccine to rule them all
Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Mina et al.
annotated by Sara Reynolds
The introduction of the measles vaccination led to a drop in childhood death rates that was greater than what could be expected by the prevention of just measles. This research...
annotations posted 07/21/2016
Empowering youth through summer jobs
Summer jobs reduce violence among disadvantaged youth. Heller.
annotated by Jessica Ham
When young adults do not have access to jobs they are more likely to be involved in violent activity that can injure or kill those involved. This suggests that there is something about having a job that keeps young adults from participating...
annotations posted 07/20/2016
Metabolic middle ground
Evidence for mesothermy in dinosaurs. Grady et al.
annotated by Valerie May
For several decades, researchers have struggled to determine whether dinosaurs had energetic systems closer to those of rapidly metabolizing endotherms like mammals and birds, or to those of slower, ectothermic reptiles that do not...
annotations posted 07/19/2016